Endocrine Abstracts

The impairment of cognitive function found in patients treated for pituitary adenomas has been associated with the effects of conventional radiotherapy (CR). Our aim was to compare the results of an examination of verbal memory function in acromegalic patients treated with transsphenoidal surgery (TS) alone to those obtained from patients treated with TS followed by CR. We retrospectively compared these two outcome groups and carried out a story recall test that included free ...

Neurocognitive dysfunction has been described in patients following pituitary radiotherapy. However, the relative contributions of other variables such as hormone-deficiency states and surgery is still unknown. Our aim was to compare the results of an examination of executive function in acromegalic patients treated with transsphenoidal surgery (TS) alone to those obtained from patients treated with TS followed by conventional radiotherapy (CR) using a two-field technique. We ...

BackgroundMultiple Endocrine Neoplasia type 1 (MEN 1) is a genetic syndrome caused by inactivating mutations of the menin gene, which predisposes to the development of endocrine tumors. The causative mutations, clinical manifestations, and age of tumor development are highly variable. The objective of this study is to describe the characteristics of patients with MEN1 in our hospital.Material and methodsWe pe...

Introduction: Recent studies suggest that some patients initially diagnosed with congenital hypogonadotropic hypogonadism (CHH), may evolve towards a combined pituitary hormonal deficiency (CPHD). Heterozygous pathogenic CHD7 variants impair neural cell crest guidance causing CHARGE syndrome and have been associated with abnormal pituitary development/function/structure and isolated CHARGE features, including HH. We aimed to genotype CHD7 and phenotype thoroughly those adult p...

Introduction: Medullary thyroid carcinoma (MTC) commonly metastasizes to cervical lymph nodes, liver, lungs and bone. Metastatic lesions in the breast have been previously reported but they are extremely rare and to our knowledge, this is the first case in literature described on a male patient. We report a case of a 49-year-old man with a 23-year history of sporadic MTC with bone, liver and lung metastases treated with somatostatin analogues for 6 years, who developed a painf...

Introduction: The use of Bisphosphonates could be a treatment option of osteoporosis secondary to primary hyperparathyroidism (OPHP) in patients not eligible or that refuse/reject surgery.Methods/design: We analysed data of 46 patients diagnosed of OPHP. Fourteen underwent surgery and 32 were treated with bisphosphonates at standard dose. Densitometric parameters and of calcium-phosphorus metabolism were analyzed before and after 1 and 2 years of treatme...

Introduction: Growth hormone deficiency (GHD) is associated with worsening body composition and growth hormone replacement therapy (GHRT) has shown to improve it in several studies. The objectives of this study were to evaluate the effects of long-term GHRT on body composition in adult patients with GHD andassess, in this population, the agreement between two different methods to measure fat mass that are total body fat mass (FM) and relative fat mass (RFM).<p class="abste...

Introduction: The availability of an increasing therapeutic arsenal for endocrine diseases seems to explain the current trend towards a decrease in the indications of endocrine surgery. However, this trend requires a detailed study before being confirmed in our setting.Objectives: We aimed to assess the trends in the performance of endocrine surgery, in children and adults, during three consecutive years (2014, 2015 and 2016) in our University Tertiary-C...

Introduction: Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS related GH excess, and complicates their neurosurgical approach. We describe a 21-year-old male with severe craniofacial fibrous dysplasia and acute obstructive hydrocephalus due to a 39×35 mm cystic lesion in the third ventricle that occluded Monro’s foramina, in whom MAS and long-term untreated acromegaly were discovered.<p cla...

Introduction: MTC accounts for 5% of thyroid cancers and can occur sporadically or as part of the multiple endocrine neoplasia type 2 syndrome (MEN 2). The objective of our study is to evaluate the prognostic factors and outcomes of patients with MTC in the community setting.Methods: Retrospective descriptive multicenter study of patients with histological diagnosis of MTC. Descriptive, bivariate analyses (Student t for cuantitative and ...